Below you will find a list of the ten key discoveries of CFS research over the past 20 years. You can read the entire summary at this link from the CFIDS Association of America. This research summary was provided by Dr. Anthony Komaroff, a professor of medicine at Harvard Medical School. He is also the senior physician at Brigham and Women’s Hospital in Boston and the editor-in-chief of Harvard Health Publications.
1. Chronic Fatigue Syndrome is not a form of depression and many patients with CFS have no diagnosable psychiatric disorder.
2. There’s a state of chronic, low-grade immune activation in Chronic Fatigue Syndrome.
3. There is substantial evidence of poorly functioning natural killer cells, which are the white blood cells vital in in fighting viral infections.
4. Abnormalities in the white matter of the brain have been found in CFS patients using MRI scans.
5. Abnormalities in brain metabolism have been discovered.
6. CFS patients experience abnormalities in multiple neuroendocrine systems in the brain: hypothalamic-pituitary-adrenal axis.
7. Cognitive impairment is commonly found in CFS patients.
8. Abnormalities of the autonomic nervous system have been found by several independent researchers.
9. CFS patients have disordered expression of genes that are important in energy metabolism.
10. There is evidence of more frequent latent active infection of Epstein Barr, HHV-6, and cytomegalovirus.