An alarming high amount of CFIDS patients (85% – 95%) report having cognitive difficulties. There has been new research from two independent international groups that suggests that the volume of gray matter in the brain of CFIDS patients is significantly decreased. The decrease in brain tissue (cerebral atrophy) may be responsible for cognitive problems in some CFIDS patients.
A recent study from 2005 that was conducted in the Netherlands used MRI to measure brain volume and tissue concentration in CFIDS patients. They found that the volume of gray matter was significantly decreased.
What is especially interesting is that after researchers found structural abnormalities in their first CFIDS study, they repeated the experiment in a second study and found the same results.
Research has not shown yet though if the decrease in brain tissue is a cause of CFIDS or a consequence.