Pooled cerebrospinal fluid (CSF) samples from nPTLS patients, CFS patients, and healthy volunteers were comprehensively analyzed using high-resolution mass spectrometry (MS), coupled with immunoaffinity depletion methods to reduce protein-masking by abundant proteins. Individual patient and healthy control CSF samples were analyzed directly employing a MS-based label-free quantitative proteomics approach. We found that both groups, and individuals within the groups, could be distinguished from each other and normals based on their specific CSF proteins.
Non-redundant protein levels of CFS patients = 2,783
Non-redundant protein levels of post-treatment Lyme patients = 2,768
Non-redundant protein levels of healthy control subjects = 2,630
I remember reading back a few years ago something that had to do with spinal fluid and the problems it may cause in ME/CFS patients. At the time, I believe the doctors/researchers were saying that we have a build up of spinal fluid that needs to be relieved. Spinal taps, I believe, were being discussed to help treat ME/CFS. Does anyone remember this?