A recent study in the American Journal of Medicine, that was conducted by Dr. Elke Van Hoof, compiled information from a large sleep study base of ME/CFS patients. They were looking for a common theme and relationship to “deregulation of the RNase L antiviral pathwayan immune dysfunction common to a subset of CFS patients. RNase L is the key enzyme in the body’s antiviral pathway.”
Results showed that subjects experienced prolonged trouble initiating sleep, poor sleep efficiency and less slow-wave deep sleep. The alpha-delta wave intrusion, however, appeared to be correlated to anxiety rather than immunologic parameters such as deregulated RNase L. So while this study didn’t find a connection between sleep problems and RNase L, it did validate sleep latency and efficiency problems in CFS patients as well as alpha-delta wave intrusion.